The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase

The prion protein (PrP(C)) is a cell surface glycoprotein mainly expressed in neurons, whose misfolded isoforms generate the prion responsible for incurable neurodegenerative disorders. Whereas PrP(C) involvement in prion propagation is well established, PrP(C) physiological function is still enigma...

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Publicado en:Front Cell Neurosci
Autores principales: De Mario, Agnese, Castellani, Angela, Peggion, Caterina, Massimino, Maria Lina, Lim, Dmitry, Hill, Andrew F., Sorgato, M. Catia, Bertoli, Alessandro
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623396/
https://ncbi.nlm.nih.gov/pubmed/26578881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00416
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