First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers

This first-in-human study examined the safety and pharmacokinetics of ch-mAb7F9, an anti-methamphetamine monoclonal antibody, in healthy volunteers. Single, escalating doses of ch-mAb7F9 over the range of 0.2 to 20 mg/kg were administered to 42 subjects who were followed for 147 d. Safety was measur...

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Publicado en:MAbs
Autores principales: Stevens, Misty W, Henry, Ralph L, Owens, S Michael, Schutz, Ralph, Gentry, W Brooks
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2014
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Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623385/
https://ncbi.nlm.nih.gov/pubmed/25484042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.976431
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