MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish

Altered phosphodiesterase (PDE)-cyclic AMP (cAMP) activity is frequently associated with anxiety disorders, but current therapies act by reducing neuronal excitability rather than targeting PDE-cAMP-mediated signaling pathways. Here, we report the novel repositioning of anti-cancer MEK inhibitors as...

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Publicat a:Chem Biol
Autors principals: Lundegaard, Pia R., Anastasaki, Corina, Grant, Nicola J., Sillito, Rowland R., Zich, Judith, Zeng, Zhiqiang, Paranthaman, Karthika, Larsen, Anders Peter, Armstrong, J. Douglas, Porteous, David J., Patton, E. Elizabeth
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623357/
https://ncbi.nlm.nih.gov/pubmed/26388333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.08.010
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