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The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development

BACKGROUND: Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic mouse mammary tumor virus (MMTV) insertions. INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physio...

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Detalhes bibliográficos
Main Authors: Grzmil, Michal, Whiting, Danny, Maule, John, Anastasaki, Corina, Amatruda, James F., Kelsh, Robert N., Norbury, Chris J., Patton, E. Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978538/
https://ncbi.nlm.nih.gov/pubmed/17895999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000959
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