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Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs
Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and distributor of compounds including drugs. In humans, serum albumin exhibits an unusually long half-life mainly due to protection from catabolism by neonatal Fc receptor (FcRn)-mediated recycling. These p...
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Publicado no: | MAbs |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Taylor & Francis
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623309/ https://ncbi.nlm.nih.gov/pubmed/25654695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1008345 |
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