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Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs

Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and distributor of compounds including drugs. In humans, serum albumin exhibits an unusually long half-life mainly due to protection from catabolism by neonatal Fc receptor (FcRn)-mediated recycling. These p...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Roopenian, Derry C, Low, Benjamin E, Christianson, Gregory J, Proetzel, Gabriele, Sproule, Thomas J, Wiles, Michael V
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623309/
https://ncbi.nlm.nih.gov/pubmed/25654695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1008345
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