Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells

Recent studies indicate that post-translational protein neddylation is required for the maintenance of cell viability in several lymphoma cell lines, while inhibition of the neddylation pathway with an NEDD8-activating enzyme (NAE) inhibitor MLN4924 induces apoptosis in lymphoma cells. However, the...

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Udgivet i:Cancer Biol Ther
Main Authors: Wang, Yanchun, Luo, Zhongguang, Pan, Yongfu, Wang, Weige, Zhou, Xiaoyan, Jeong, Lak Shin, Chu, Yiwei, Liu, Jie, Jia, Lijun
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623239/
https://ncbi.nlm.nih.gov/pubmed/25782162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2014.1003003
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