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mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels
Mechanistic target of rapamycin (mTOR) is a master regulator of cell growth through its ability to stimulate ribosome biogenesis and mRNA translation. In contrast, the p53 tumor suppressor negatively controls cell growth and is activated by a wide range of insults to the cell. The mTOR and p53 signa...
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| Udgivet i: | Cancer Biol Ther |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623102/ https://ncbi.nlm.nih.gov/pubmed/25482947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.955743 |
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