Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma

Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and cetuximab, a monoclonal antibody targeting this receptor, is widely used to treat these patients. In the following investigation, we examined the role of SMAD4 down-regulation in...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Cheng, Haixia, Fertig, Elana J, Ozawa, Hiroyuki, Hatakeyama, Hiromitsu, Howard, Jason D, Perez, Jimena, Considine, Michael, Thakar, Manjusha, Ranaweera, Ruchira, Krigsfeld, Gabriel, Chung, Christine H
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623002/
https://ncbi.nlm.nih.gov/pubmed/26046389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1056418
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