Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma

BACKGROUND: Aberrant activation of signaling pathways downstream of epidermal growth factor receptor (EGFR) has been hypothesized to be one of the mechanisms of cetuximab (a monoclonal antibody against EGFR) resistance in head and neck squamous cell carcinoma (HNSCC). To infer relevant and specific...

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Hauptverfasser: Fertig, Elana J, Ren, Qing, Cheng, Haixia, Hatakeyama, Hiromitsu, Dicker, Adam P, Rodeck, Ulrich, Considine, Michael, Ochs, Michael F, Chung, Christine H
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460736/
https://ncbi.nlm.nih.gov/pubmed/22549044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-160
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