Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform

Camelid immunoglobulin variable (IGV) regions were found homologous to their human counterparts; however, the germline V repertoires of camelid heavy and light chains are still incomplete and their therapeutic potential is only beginning to be appreciated. We therefore leveraged the publicly availab...

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Vydáno v:MAbs
Hlavní autoři: Klarenbeek, Alex, Mazouari, Khalil El, Desmyter, Aline, Blanchetot, Christophe, Hultberg, Anna, de Jonge, Natalie, Roovers, Rob C, Cambillau, Christian, Spinelli, Sylvia, Del-Favero, Jurgen, Verrips, Theo, de Haard, Hans J, Achour, Ikbel
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622956/
https://ncbi.nlm.nih.gov/pubmed/26018625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1046648
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