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Boosting antibody developability through rational sequence optimization

The application of monoclonal antibodies as commercial therapeutics poses substantial demands on stability and properties of an antibody. Therapeutic molecules that exhibit favorable properties increase the success rate in development. However, it is not yet fully understood how the protein sequence...

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Bibliografische gegevens
Gepubliceerd in:MAbs
Hoofdauteurs: Seeliger, Daniel, Schulz, Patrick, Litzenburger, Tobias, Spitz, Julia, Hoerer, Stefan, Blech, Michaela, Enenkel, Barbara, Studts, Joey M, Garidel, Patrick, Karow, Anne R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622947/
https://ncbi.nlm.nih.gov/pubmed/25759214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1017695
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