Boosting antibody developability through rational sequence optimization

The application of monoclonal antibodies as commercial therapeutics poses substantial demands on stability and properties of an antibody. Therapeutic molecules that exhibit favorable properties increase the success rate in development. However, it is not yet fully understood how the protein sequence...

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Publicado en:MAbs
Main Authors: Seeliger, Daniel, Schulz, Patrick, Litzenburger, Tobias, Spitz, Julia, Hoerer, Stefan, Blech, Michaela, Enenkel, Barbara, Studts, Joey M, Garidel, Patrick, Karow, Anne R
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
Assuntos:
Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622947/
https://ncbi.nlm.nih.gov/pubmed/25759214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1017695
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