Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells

The TET family of dioxygenases (TET1/2/3) can convert 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and has been shown to be involved in active and passive DNA demethylation. Here, we demonstrate that altering TET dioxygenase levels within physiological range can affect DNA methylation...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Grosser, Christian, Wagner, Nicholas, Grothaus, Katrin, Horsthemke, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622922/
https://ncbi.nlm.nih.gov/pubmed/26186463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1073879
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