Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase

Insights on active DNA demethylation disproved the original assumption that DNA methylation is a stable epigenetic modification. Interestingly, mammalian DNA methyltransferases 3A and 3B (DNMT-3A and -3B) have also been reported to induce active DNA demethylation, in addition to their well-known fun...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: van der Wijst, Monique G P, Venkiteswaran, Muralidhar, Chen, Hui, Xu, Guo-Liang, Plösch, Torsten, Rots, Marianne G
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Point-of-View
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622917/
https://ncbi.nlm.nih.gov/pubmed/26098813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1062204
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