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The Mammalian de Novo DNA Methyltransferases DNMT3A and DNMT3B Are Also DNA 5-Hydroxymethylcytosine Dehydroxymethylases

For cytosine (C) demethylation of vertebrate DNA, it is known that the TET proteins could convert 5-methyl C (5-mC) to 5-hydroxymethyl C (5-hmC). However, DNA dehydroxymethylase(s), or enzymes able to directly convert 5-hmC to C, have been elusive. We present in vitro evidence that the mammalian de...

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Detalhes bibliográficos
Main Authors: Chen, Chun-Chang, Wang, Keh-Yang, Shen, Che-Kun James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460417/
https://ncbi.nlm.nih.gov/pubmed/22898819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.406975
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