Methylation status of IGFBP-3 as a useful clinical tool for deciding on a concomitant radiotherapy

The methylation status of the IGFBP-3 gene is strongly associated with cisplatin sensitivity in patients with non-small cell lung cancer (NSCLC). In this study, we found in vitro evidence that linked the presence of an unmethylated promoter with poor response to radiation. Our data also indicate tha...

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Publicado en:Epigenetics
Autores principales: Pernía, Olga, Belda-Iniesta, Cristobal, Pulido, Veronica, Cortes-Sempere, María, Rodriguez, Carlos, Vera, Olga, Soto, Javier, Jiménez, Julia, Taus, Alvaro, Rojo, Federico, Arriola, Edurne, Rovira, Ana, Albanell, Joan, Macías, M Teresa, de Castro, Javier, Perona, Rosario, Ibañez de Caceres, Inmaculada
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2014
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622698/
https://ncbi.nlm.nih.gov/pubmed/25482372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.971626
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