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MLH1 constitutional and somatic methylation in patients with MLH1 negative tumors fulfilling the revised Bethesda criteria
Lynch syndrome (LS) is a tumor predisposing condition caused by constitutional defects in genes coding for components of the mismatch repair (MMR) apparatus. While hypermethylation of the promoter of the MMR gene MLH1 occurs in about 15% of colorectal cancer samples, it has also been observed as a c...
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Udgivet i: | Epigenetics |
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Main Authors: | , , , , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Taylor & Francis
2014
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4622593/ https://ncbi.nlm.nih.gov/pubmed/25437057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.970080 |
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