hMLH1 promoter methylation and BRAF mutations in high-frequency microsatellite instability colorectal cancers not fulfilling the revised Bethesda guidelines

PURPOSE: Sporadic colorectal cancers with high-frequency microsatellite instability (MSI-H) are related to hypermethylation of mismatch repair (MMR) genes and a higher frequency of BRAF mutations than Lynch syndrome. We estimated the feasibility of hereditary colorectal cancer based on hMLH1 methyla...

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Detalhes bibliográficos
Main Authors: Kim, Sang Jin, Kim, Hyoung Ran, Kim, Seok Hyung, Han, Ji Hye, Cho, Yong Beom, Yun, Seong Hyeon, Lee, Woo Yong, Kim, Hee Cheol
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Surgical Society 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170578/
https://ncbi.nlm.nih.gov/pubmed/25247165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4174/astr.2014.87.3.123
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