MLH1 constitutional and somatic methylation in patients with MLH1 negative tumors fulfilling the revised Bethesda criteria

Lynch syndrome (LS) is a tumor predisposing condition caused by constitutional defects in genes coding for components of the mismatch repair (MMR) apparatus. While hypermethylation of the promoter of the MMR gene MLH1 occurs in about 15% of colorectal cancer samples, it has also been observed as a c...

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Bibliographic Details
Published in:Epigenetics
Main Authors: Crucianelli, Francesca, Tricarico, Rossella, Turchetti, Daniela, Gorelli, Greta, Gensini, Francesca, Sestini, Roberta, Giunti, Laura, Pedroni, Monica, Ponz de Leon, Maurizio, Civitelli, Serenella, Genuardi, Maurizio
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622593/
https://ncbi.nlm.nih.gov/pubmed/25437057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.970080
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