MLH1 constitutional and somatic methylation in patients with MLH1 negative tumors fulfilling the revised Bethesda criteria

Lynch syndrome (LS) is a tumor predisposing condition caused by constitutional defects in genes coding for components of the mismatch repair (MMR) apparatus. While hypermethylation of the promoter of the MMR gene MLH1 occurs in about 15% of colorectal cancer samples, it has also been observed as a c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Epigenetics
Prif Awduron: Crucianelli, Francesca, Tricarico, Rossella, Turchetti, Daniela, Gorelli, Greta, Gensini, Francesca, Sestini, Roberta, Giunti, Laura, Pedroni, Monica, Ponz de Leon, Maurizio, Civitelli, Serenella, Genuardi, Maurizio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2014
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622593/
https://ncbi.nlm.nih.gov/pubmed/25437057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.970080
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