Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry

CTLA4-Ig is a highly glycosylated therapeutic fusion protein that contains multiple N- and O-glycosylation sites. Glycosylation plays a vital role in protein solubility, stability, serum half-life, activity, and immunogenicity. For a CTLA4-Ig biosimilar development program, comparative analytical da...

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Publicat a:MAbs
Autors principals: Zhu, Lei, Guo, Qingcheng, Guo, Huaizu, Liu, Tao, Zheng, Yingxin, Gu, Peiming, Chen, Xi, Wang, Hao, Hou, Sheng, Guo, Yajun
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2014
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622558/
https://ncbi.nlm.nih.gov/pubmed/25484062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.36313
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