Generation and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency

Panitumumab, as a commercially available antibody, is an effective anticancer therapeutic against epidermal growth factor receptor (EGFR), although it exerts weak antibody-dependent cell-mediated cytotoxicity (ADCC) activity owing to its IgG2 nature. Here, we firstly engineered panitumumab by grafti...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Yang, Yun, Guo, Qingcheng, Xia, Mao, Li, Yantao, Peng, Xiaoyun, Liu, Tao, Tong, Xin, Xu, Jin, Guo, Huaizu, Qian, Weizhu, Hou, Sheng, Dai, Jianxin, Wang, Hao, Liu, Rong, Guo, Yajun
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622528/
https://ncbi.nlm.nih.gov/pubmed/25679409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1008352
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