Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy

VEGF/VEGFR signal axis has been proven to be an important target for development of novel cancer therapies. One challenging aspect in small molecular VEGFR inhibitors is to achieve sustained target inhibition at tolerable doses previously seen only with the long-acting biologics. It would require hi...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer Biol Ther
Autori principali: Sun, Qiaoling, Zhou, Jinghong, Zhang, Zheng, Guo, Mingchuan, Liang, Junqing, Zhou, Feng, Long, Jingwen, Zhang, Wei, Yin, Fang, Cai, Huaqing, Yang, Haibin, Zhang, Weihan, Gu, Yi, Ni, Liang, Sai, Yang, Cui, Yumin, Zhang, Meifang, Hong, Minhua, Sun, Junen, Yang, Zheng, Qing, Weiguo, Su, Weiguo, Ren, Yongxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2014
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622458/
https://ncbi.nlm.nih.gov/pubmed/25482937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.964087
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