Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification

Targeted therapy is not yet approved for esophageal cancer (EC). In this study, we first evaluated EGFR gene and protein expression in 70 Chinese EC patient tumor samples collected during surgery. We then established 23 patient-derived EC xenograft (PDECX) models and assessed the efficacy of theliat...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ren, Yongxin, Zheng, Jianming, Fan, Shiming, Wang, Linfang, Cheng, Min, Shi, Dongxia, Zhang, Wei, Tang, Renxiang, Yu, Ying, Jiao, Longxian, Ni, Jun, Yang, Haibin, Cai, Huaqing, Yin, Fang, Chen, Yunxin, Zhou, Feng, Zhang, Weihan, Qing, Weiguo, Su, Weiguo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584209/
https://ncbi.nlm.nih.gov/pubmed/28881608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17243
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