Volitinib, a potent and highly selective c‐Met inhibitor, effectively blocks c‐Met signaling and growth in c‐MET amplified gastric cancer patient‐derived tumor xenograft models

PURPOSE: To investigate the incidence of cMET gene copy number changes and protein overexpression in Chinese gastric cancer (GC) and to preclinically test the hypothesis that the novel, potent and selective cMET small‐molecule inhibitor volitinib, will deliver potent anti‐tumor activity in cMET‐dysr...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Gavine, Paul R., Ren, Yongxin, Han, Lu, Lv, Jing, Fan, Shiming, Zhang, Wei, Xu, Wen, Liu, Yuan Jie, Zhang, Tianwei, Fu, Haihua, Yu, Yongjuan, Wang, Huiying, Xu, Shirlian, Zhou, Feng, Su, Xinying, Yin, XiaoLu, Xie, Liang, Wang, Linfang, Qing, Weiguo, Jiao, Longxian, Su, Weiguo, Wang, Q. May
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528670/
https://ncbi.nlm.nih.gov/pubmed/25248999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.08.015
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