Volitinib, a potent and highly selective c‐Met inhibitor, effectively blocks c‐Met signaling and growth in c‐MET amplified gastric cancer patient‐derived tumor xenograft models

PURPOSE: To investigate the incidence of cMET gene copy number changes and protein overexpression in Chinese gastric cancer (GC) and to preclinically test the hypothesis that the novel, potent and selective cMET small‐molecule inhibitor volitinib, will deliver potent anti‐tumor activity in cMET‐dysr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Oncol
Egile Nagusiak: Gavine, Paul R., Ren, Yongxin, Han, Lu, Lv, Jing, Fan, Shiming, Zhang, Wei, Xu, Wen, Liu, Yuan Jie, Zhang, Tianwei, Fu, Haihua, Yu, Yongjuan, Wang, Huiying, Xu, Shirlian, Zhou, Feng, Su, Xinying, Yin, XiaoLu, Xie, Liang, Wang, Linfang, Qing, Weiguo, Jiao, Longxian, Su, Weiguo, Wang, Q. May
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2014
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528670/
https://ncbi.nlm.nih.gov/pubmed/25248999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.08.015
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