Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells

Renal cell carcinoma is an aggressive disease often asymptomatic and weakly chemo-radiosensitive. Currently, new biologic drugs are used among which everolimus, an mTOR inhibitor, that has been approved for second-line therapy. Since mTOR is involved in the control of autophagy, its antitumor capaci...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Grimaldi, A, Santini, D, Zappavigna, S, Lombardi, A, Misso, G, Boccellino, M, Desiderio, V, Vitiello, P P, Di Lorenzo, G, Zoccoli, A, Pantano, F, Caraglia, M
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622435/
https://ncbi.nlm.nih.gov/pubmed/25866016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1018494
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