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Insert engineering and solubility screening improves recovery of virus-like particle subunits displaying hydrophobic epitopes

The Polyomavirus coat protein, VP1 has been developed as an epitope presentation system able to provoke humoral immunity against a variety of pathogens, such as Influenza and Group A Streptococcus. The ability of the system to carry cytotoxic T cell epitopes on a surface-exposed loop and the impact...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Abidin, R S, Lua, L H L, Middelberg, A P J, Sainsbury, F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622215/
https://ncbi.nlm.nih.gov/pubmed/26401641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2775
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