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Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

BACKGROUND AND PURPOSE: Recently, two phase‐II trials demonstrated improved renal function in critically ill patients with sepsis‐associated acute kidney injury treated with the enzyme alkaline phosphatase. Here, we elucidated the dual active effect on renal protection of alkaline phosphatase. EXPER...

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書目詳細資料
發表在:Br J Pharmacol
Main Authors: Peters, E, Geraci, S, Heemskerk, S, Wilmer, M J, Bilos, A, Kraenzlin, B, Gretz, N, Pickkers, P, Masereeuw, R
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621995/
https://ncbi.nlm.nih.gov/pubmed/26222228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13261
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