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Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

BACKGROUND AND PURPOSE: Recently, two phase‐II trials demonstrated improved renal function in critically ill patients with sepsis‐associated acute kidney injury treated with the enzyme alkaline phosphatase. Here, we elucidated the dual active effect on renal protection of alkaline phosphatase. EXPER...

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Publicat a:Br J Pharmacol
Autors principals: Peters, E, Geraci, S, Heemskerk, S, Wilmer, M J, Bilos, A, Kraenzlin, B, Gretz, N, Pickkers, P, Masereeuw, R
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621995/
https://ncbi.nlm.nih.gov/pubmed/26222228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13261
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