Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

BACKGROUND AND PURPOSE: Recently, two phase‐II trials demonstrated improved renal function in critically ill patients with sepsis‐associated acute kidney injury treated with the enzyme alkaline phosphatase. Here, we elucidated the dual active effect on renal protection of alkaline phosphatase. EXPER...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Peters, E, Geraci, S, Heemskerk, S, Wilmer, M J, Bilos, A, Kraenzlin, B, Gretz, N, Pickkers, P, Masereeuw, R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2015
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621995/
https://ncbi.nlm.nih.gov/pubmed/26222228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13261
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