Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

BACKGROUND AND PURPOSE: Recently, two phase‐II trials demonstrated improved renal function in critically ill patients with sepsis‐associated acute kidney injury treated with the enzyme alkaline phosphatase. Here, we elucidated the dual active effect on renal protection of alkaline phosphatase. EXPER...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Peters, E, Geraci, S, Heemskerk, S, Wilmer, M J, Bilos, A, Kraenzlin, B, Gretz, N, Pickkers, P, Masereeuw, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621995/
https://ncbi.nlm.nih.gov/pubmed/26222228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13261
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