Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

BACKGROUND AND PURPOSE: Recently, two phase‐II trials demonstrated improved renal function in critically ill patients with sepsis‐associated acute kidney injury treated with the enzyme alkaline phosphatase. Here, we elucidated the dual active effect on renal protection of alkaline phosphatase. EXPER...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Peters, E, Geraci, S, Heemskerk, S, Wilmer, M J, Bilos, A, Kraenzlin, B, Gretz, N, Pickkers, P, Masereeuw, R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621995/
https://ncbi.nlm.nih.gov/pubmed/26222228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13261
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