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Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation
Hedgehog (Hh) is a secreted glycoprotein that binds its receptor Patched to activate the G protein-coupled receptor-like protein Smoothened (Smo). In Drosophila, protein kinase A (PKA) phosphorylates and activates Smo in cells stimulated with Hh. In unstimulated cells, PKA phosphorylates and inhibit...
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| Veröffentlicht in: | Sci Signal |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621970/ https://ncbi.nlm.nih.gov/pubmed/24985345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005414 |
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