The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking

Human immunodeficiency virus type 1 (HIV-1) impairs major functions of macrophages but the molecular basis for this defect remains poorly characterized. Here, we show that macrophages infected with HIV-1 were unable to respond efficiently to phagocytic triggers and to clear bacteria. The maturation...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Dumas, Audrey, Lê-Bury, Gabrielle, Marie-Anaïs, Florence, Herit, Floriane, Mazzolini, Julie, Guilbert, Thomas, Bourdoncle, Pierre, Russell, David G., Benichou, Serge, Zahraoui, Ahmed, Niedergang, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621833/
https://ncbi.nlm.nih.gov/pubmed/26504171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201503124
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