A Coiled-Coil Mimetic Intercepts BCR-ABL1 Dimerization in Native and Kinase-Mutant Chronic Myeloid Leukemia

Targeted therapy of chronic myeloid leukemia is currently based on small-molecule inhibitors that directly bind the tyrosine kinase domain of BCR-ABL1. This strategy has generally been successful, but is subject to drug resistance due to point mutations in the kinase domain. Kinase activity requires...

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Publicat a:Leukemia
Autors principals: Woessner, David W., Eiring, Anna M., Bruno, Benjamin J., Zabriskie, Matthew S., Reynolds, Kimberly R., Miller, Geoffrey D., O’Hare, Thomas, Deininger, Michael W., Lim, Carol S.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621806/
https://ncbi.nlm.nih.gov/pubmed/25721898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.53
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