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An FcγRIIa Polymorphism with Decreased C-Reactive Protein Binding is Associated with Sepsis and Decreased Monocyte HLA-DR Expression in Trauma Patients

INTRODUCTION: A dysregulated immune response leading to sepsis is the most frequent cause of late post-traumatic deaths. We have found a novel anti-inflammatory pathway that is initiated by the acute phase protein, C-reactive protein (CRP), interacting with Fcγ receptor (FcγR) on monocytes. This pat...

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Bibliographische Detailangaben
Veröffentlicht in:J Trauma Acute Care Surg
Hauptverfasser: West, Sonlee D., Ziegler, Anna, Brooks, Tamara, Krencicki, Michael, Myers, Orrin, Mold, Carolyn
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621776/
https://ncbi.nlm.nih.gov/pubmed/26496101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000000837
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