MD Simulations and FRET Reveal an Environment-Sensitive Conformational Plasticity of Importin-β

The nuclear pore complex mediates nucleocytoplasmic transport of macromolecules in eukaryotic cells. Transport through the pore is restricted by a hydrophobic selectivity filter comprising disordered phenylalanine-glycine-rich repeats of nuclear pore proteins. Exchange through the pore requires spec...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Halder, Kangkan, Dölker, Nicole, Van, Qui, Gregor, Ingo, Dickmanns, Achim, Baade, Imke, Kehlenbach, Ralph H., Ficner, Ralf, Enderlein, Jörg, Grubmüller, Helmut, Neumann, Heinz
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2015
Assuntos:
Channels and Transporters
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621615/
https://ncbi.nlm.nih.gov/pubmed/26200863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.014
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