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Structural basis for m(7)G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1

The 5′-cap of spliceosomal small nuclear RNAs, some small nucleolar RNAs and of telomerase RNA was found to be hypermethylated in vivo. The Trimethylguanosine Synthase 1 (TGS1) mediates this conversion of the 7-methylguanosine-cap to the 2,2,7-trimethylguanosine (m(3)G)-cap during maturation of the...

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書誌詳細
主要な著者: Monecke, Thomas, Dickmanns, Achim, Ficner, Ralf
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709555/
https://ncbi.nlm.nih.gov/pubmed/19386620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp249
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