Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts

The ability to generate integration-free induced hepatocyte-like cells (iHeps) from somatic fibroblasts has the potential to advance their clinical application. Here, we have generated integration-free, functional, and expandable iHeps from mouse somatic fibroblasts. To elicit this direct conversion...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kim, Jonghun, Kim, Kee-Pyo, Lim, Kyung Tae, Lee, Seung Chan, Yoon, Juyong, Song, Guangqi, Hwang, Seon In, Schöler, Hans R., Cantz, Tobias, Han, Dong Wook
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621602/
https://ncbi.nlm.nih.gov/pubmed/26503743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15706
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