Titin Domains Progressively Unfolded by Force Are Homogenously Distributed along the Molecule

Titin is a giant filamentous protein of the muscle sarcomere in which stretch induces the unfolding of its globular domains. However, the mechanisms of how domains are progressively selected for unfolding and which domains eventually unfold have for long been elusive. Based on force-clamp optical tw...

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Bibliographic Details
Published in:Biophys J
Main Authors: Bianco, Pasquale, Mártonfalvi, Zsolt, Naftz, Katalin, Kőszegi, Dorina, Kellermayer, Miklós
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Molecular Machines, Motors, and Nanoscale Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621543/
https://ncbi.nlm.nih.gov/pubmed/26200869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.002
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