Titin Domains Progressively Unfolded by Force Are Homogenously Distributed along the Molecule

Titin is a giant filamentous protein of the muscle sarcomere in which stretch induces the unfolding of its globular domains. However, the mechanisms of how domains are progressively selected for unfolding and which domains eventually unfold have for long been elusive. Based on force-clamp optical tw...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Bianco, Pasquale, Mártonfalvi, Zsolt, Naftz, Katalin, Kőszegi, Dorina, Kellermayer, Miklós
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2015
Fag:
Molecular Machines, Motors, and Nanoscale Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621543/
https://ncbi.nlm.nih.gov/pubmed/26200869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.002
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