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HIGH-THROUGHPUT ANALYSIS OF DRUG DISSOCIATION FROM SERUM PROTEINS USING AFFINITY SILICA MONOLITHS
A noncompetitive peak decay method was used with 1 mm × 4.6 mm i.d. silica monoliths to measure the dissociation rate constants (k(d)) for various drugs with human serum albumin (HSA) and α(1)-acid glycoprotein (AGP). Flow rates up to 9 mL/min were used in these experiments, resulting in analysis ti...
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| Publicado no: | J Sep Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4620944/ https://ncbi.nlm.nih.gov/pubmed/21661111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jssc.201100280 |
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