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HIGH-THROUGHPUT ANALYSIS OF DRUG DISSOCIATION FROM SERUM PROTEINS USING AFFINITY SILICA MONOLITHS

A noncompetitive peak decay method was used with 1 mm × 4.6 mm i.d. silica monoliths to measure the dissociation rate constants (k(d)) for various drugs with human serum albumin (HSA) and α(1)-acid glycoprotein (AGP). Flow rates up to 9 mL/min were used in these experiments, resulting in analysis ti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Sep Sci
Hauptverfasser: Yoo, Michelle J., Hage, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620944/
https://ncbi.nlm.nih.gov/pubmed/21661111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jssc.201100280
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