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USE OF PEAK DECAY ANALYSIS AND AFFINITY MICROCOLUMNS CONTAINING SILICA MONOLITHS FOR RAPID DETERMINATION OF DRUG-PROTEIN DISSOCIATION RATES

This report examined the use of silica monoliths in affinity microcolumns containing human serum albumin (HSA) to measure the dissociation rates for various drugs from this protein. Immobilized HSA and control monolith columns with dimensions of 1 mm × 4.6 mm i.d. were prepared for this work and use...

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Bibliografiska uppgifter
Huvudupphovsmän: Yoo, Michelle J., Hage, David S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024456/
https://ncbi.nlm.nih.gov/pubmed/20956006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2010.09.070
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