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EVALUATION OF AFFINITY MICROCOLUMNS CONTAINING HUMAN SERUM ALBUMIN FOR RAPID ANALYSIS OF DRUG-PROTEIN BINDING

This study examined the use of affinity microcolumns as tools for the rapid analysis and high-throughput screening of drug-protein binding. The protein used was immobilized human serum albumin (HSA) and the model analytes were warfarin and L-tryptophan, two solutes often used as site-specific probes...

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Bibliografiske detaljer
Main Authors: Yoo, Michelle J., Schiel, John E., Hage, David S.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878846/
https://ncbi.nlm.nih.gov/pubmed/20462808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2010.04.028
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