Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays

Genes with similar transcriptional activation kinetics can display very different temporal mRNA profiles because of differences in transcription time, degradation rate, and RNA-processing kinetics. Recent studies have shown that a splicing-associated RNA production delay can be significant. To inves...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Honkela, Antti, Peltonen, Jaakko, Topa, Hande, Charapitsa, Iryna, Matarese, Filomena, Grote, Korbinian, Stunnenberg, Hendrik G., Reid, George, Lawrence, Neil D., Rattray, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620908/
https://ncbi.nlm.nih.gov/pubmed/26438844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420404112
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