Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapit...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Freedman, Benjamin S., Brooks, Craig R., Lam, Albert Q., Fu, Hongxia, Morizane, Ryuji, Agrawal, Vishesh, Saad, Abdelaziz F., Li, Michelle K., Hughes, Michael R., Werff, Ryan Vander, Peters, Derek T., Lu, Junjie, Baccei, Anna, Siedlecki, Andrew M., Valerius, M. Todd, Musunuru, Kiran, McNagny, Kelly M., Steinman, Theodore I., Zhou, Jing, Lerou, Paul H., Bonventre, Joseph V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Group 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620584/
https://ncbi.nlm.nih.gov/pubmed/26493500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9715
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