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Exceptionally large entropy contributions enable the high rates of GTP hydrolysis on the ribosome

Protein synthesis on the ribosome involves hydrolysis of GTP in several key steps of the mRNA translation cycle. These steps are catalyzed by the translational GTPases of which elongation factor Tu (EF-Tu) is the fastest GTPase known. Here, we use extensive computer simulations to explore the origin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Åqvist, Johan, Kamerlin, Shina C.L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620562/
https://ncbi.nlm.nih.gov/pubmed/26497916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15817
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