Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

We previously integrated dosimetry and exposure with high-throughput screening (HTS) to enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to oral equivalent doses (OEDs) required to achieve these levels internally. These OEDs were compared against regulatory...

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Detalles Bibliográficos
Publicado en:Toxicol Sci
Main Authors: Wetmore, Barbara A., Wambaugh, John F., Allen, Brittany, Ferguson, Stephen S., Sochaski, Mark A., Setzer, R. Woodrow, Houck, Keith A., Strope, Cory L., Cantwell, Katherine, Judson, Richard S., LeCluyse, Edward, Clewell, Harvey J., Thomas, Russell S., Andersen, Melvin E.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Linking High Throughput Exposure Estimates with Biological Activity for Toxicity Testing
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620046/
https://ncbi.nlm.nih.gov/pubmed/26251325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv171
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