CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancer development. We found that intratumoral CCL2 levels increased in patients with colitis-associated colorectal canc...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Chun, Eunyoung, Lavoie, Sydney, Michaud, Monia, Gallini, Carey Ann, Kim, Jason, Soucy, Genevieve, Odze, Robert, Glickman, Jonathan N., Garrett, Wendy S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620029/
https://ncbi.nlm.nih.gov/pubmed/26146082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.024
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