Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the innate immune system. Here, we report that the majority of T-bet(−/−) RAG2(−/−) ulcerative colitis (TRUC) mice spontaneously progress to colonic dysplasia and rectal adenocarcinoma solely as a consequence o...

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Detalhes bibliográficos
Main Authors: Garrett, Wendy S., Punit, Shivesh, Gallini, Carey A., Michaud, Monia, Zhang, Dorothy, Sigrist, Kirsten S., Lord, Graham M., Glickman, Jonathan N., Glimcher, Laurie H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740755/
https://ncbi.nlm.nih.gov/pubmed/19732721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.07.015
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