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Nod/Ripk2 signaling in dendritic cells activates IL-17A–secreting innate lymphoid cells and drives colitis in T-bet(−/−).Rag2(−/−) (TRUC) mice
T-bet(−/−).Rag2(−/−) (TRUC) mice spontaneously develop microbiota-driven, TNF-mediated large bowel inflammation that resembles human ulcerative colitis. We show here that IL-23 and IL-1–dependent secretion of IL-17A by innate lymphoid cells (ILCs; defined as CD45(+)lin(−)Thy1(hi)NKp46(−)) is a secon...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078823/ https://ncbi.nlm.nih.gov/pubmed/24927559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408540111 |
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