Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Lauková, Jarmila, Kozubík, Alois, Hofmanová, Jiřina, Nekvindová, Jana, Sova, Petr, Moyer, Mary Pat, Ehrmann, Jiří, Hyršlová Vaculová, Alena
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619604/
https://ncbi.nlm.nih.gov/pubmed/26492315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141020
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